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1

Inhibition of human glioma cell proliferation by altered Bax/Bcl-2-p53 expression and apoptosis induction by Rhaponticum carthamoides extracts from transformed and normal roots

Skała, Ewa, Sitarek, Przemysław, Toma, Monika, Szemraj, Janusz, Radek, Maciej, Nieborowska-Skorska, Malgorzata, Skorski, Tomasz, Wysokińska, Halina, Śliwiński, Tomasz

Journal:

Journal of Pharmacy and Pharmacology

Year:

2016

Language:

english

File:

PDF, 651 KB

english, 2016

2

59PNot only gene mutation matters: Development of flow cytometry panel to determine BRCA2 deficiency for personalised therapy by PARP inhibitors in pancreatic cancers

Chroscicki, P, Tybuchowska, A M, Swatler, J, Samsel, R, Cichocki, A, Podszywalow-Bartnicka, P, Roszkowska-Purska, K, Tenderenda, M, Smiertka, W, Nieborowska-Skorska, M, Skorski, T, Piwocka, K

Journal:

Annals of Oncology

Year:

2019

File:

PDF, 76 KB

2019

3

PARP1 inhibitor eliminated imatinib-refractory chronic myeloid leukemia cells in bone marrow microenvironment conditions

Podszywalow-Bartnicka, Paulina, Maifrede, Silvia, Le, Bac Viet, Nieborowska-Skorska, Margaret, Piwocka, Katarzyna, Skorski, Tomasz

Journal:

Leukemia and Lymphoma

Year:

2018

Language:

english

File:

PDF, 732 KB

english, 2018

4

Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors

Nieborowska-Skorska, M., Kopinski, P. K., Ray, R., Hoser, G., Ngaba, D., Flis, S., Cramer, K., Reddy, M. M., Koptyra, M., Penserga, T., Glodkowska-Mrowka, E., Bolton, E., Holyoake, T. L., Eaves, C. J.

Journal:

Year:

2012

Language:

english

File:

PDF, 1.15 MB

english, 2012

5

BCR-ABL1 kinase facilitates localization of acetylated histones 3 and 4 on DNA double-strand breaks

Rafal Falinski, Margaret Nieborowska-Skorska, Tomasz Skorski

Journal:

Leukemia Research

Year:

2012

Language:

english

File:

PDF, 636 KB

english, 2012

6

Anti-oxidant vitamin E prevents accumulation of imatinib-resistant BCR-ABL1 kinase mutations in CML-CP xenografts in NSG mice

Nieborowska-Skorska, M, Hoser, G, Hochhaus, A, Stoklosa, T, Skorski, T

Journal:

Year:

2013

Language:

english

File:

PDF, 173 KB

english, 2013

7

31. Inhibition of proliferation by c-myb antisense RNA and oligodeoxynucleotidas in transformed neuroectodermal cell lines

Raschella, G, Negreni, A, Skorski, T, Pucci, S, Nieborowska-Skorska, M, Romeo, A, Calabretta, B

Journal:

Biomedicine & Pharmacotherapy

Year:

1992

Language:

english

File:

PDF, 74 KB

english, 1992

8

BCR/ABL and Other Kinases from Chronic Myeloproliferative Disorders Stimulate Single-Strand Annealing, an Unfaithful DNA Double-Strand Break Repair

Cramer, K., Nieborowska-Skorska, M., Koptyra, M., Slupianek, A., Penserga, E. T. P., Eaves, C. J., Aulitzky, W., Skorski, T.

Journal:

Cancer Research

Year:

2008

Language:

english

File:

PDF, 397 KB

english, 2008

9

Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile

Cramer-Morales, K., Nieborowska-Skorska, M., Scheibner, K., Padget, M., Irvine, D. A., Sliwinski, T., Haas, K., Lee, J., Geng, H., Roy, D., Slupianek, A., Rassool, F. V., Wasik, M. A., Childers, W., C

Journal:

Year:

2013

Language:

english

File:

PDF, 2.25 MB

english, 2013

10

Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms

Nieborowska-Skorska, Margaret, Maifrede, Silvia, Dasgupta, Yashodhara, Sullivan, Katherine, Flis, Sylwia, Le, Bac Viet, Solecka, Martyna, Belyaeva, Elizaveta A., Kubovcakova, Lucia, Nawrocki, Morgan,

Journal:

Year:

2017

Language:

english

File:

PDF, 3.18 MB

english, 2017

11

PKC epsilon is a Key Regulator of Mitochondrial Redox Homeostasis in Acute Myeloid Leukemia

Di Marcantonio, Daniela, Martinez, Esteban, Sidoli, Simone, Vadaketh, Jessica, Nieborowska-Skorska, Margaret, Gupta, Anushk, Meadows, Jacob Michael, Ferraro, Francesca, Masselli, Elena, Challen, Grant

Journal:

Clinical Cancer Research

Year:

2017

Language:

english

File:

PDF, 3.14 MB

english, 2017

12

Effect of bcr-abl oligodeoxynucleotides on the clonogenic growth of chronic myelogenous leukaemia cells

de Fabritiis, P, Skorski, T, De Propris, M S, Paggi, M G, Nieborowska-Skorska, M, Lisci, A, Buffolino, S, Campbell, K, Geiser, T, Calabretta, B

Journal:

Year:

1997

Language:

english

File:

PDF, 501 KB

english, 1997

13

Appointments.

Raschella, G, Negreni, A, Skorski, T, Pucci, S, Nieborowska-Skorska, M, Romeo, A, Calabretta, B

Journal:

Year:

1934

Language:

english

File:

PDF, 208 KB

english, 1934

14

Drugging DNA repair to target T-ALL cells

Dasgupta, Yashodhara, Golovine, Konstantin, Nieborowska-Skorska, Margaret, Luo, Li, Matlawska-Wasowska, Ksenia, Mullighan, Charles G., Skorski, Tomasz

Journal:

Leukemia and Lymphoma

Year:

2017

Language:

english

File:

PDF, 971 KB

english, 2017

15

4435591 Compound with analgesic, antiinflammatory and antipyretic activity, and pharmaceutical compositions therefrom

Raschella, G, Negreni, A, Skorski, T, Pucci, S, Nieborowska-Skorska, M, Romeo, A, Calabretta, B

Journal:

General Pharmacology: The Vascular System

Year:

1984

Language:

english

File:

PDF, 74 KB

english, 1984

16

Non-NAD-like PARP1 inhibitor enhanced synthetic lethal effect of NAD-like PARP inhibitors against BRCA1-deficient leukemia

Nieborowska-Skorska, Margaret, Maifrede, Silvia, Ye, Min, Toma, Monika, Hewlett, Elizabeth, Gordon, John, Le, Bac Viet, Sliwinski, Tomasz, Zhao, Huaqing, Piwocka, Katarzyna, Valent, Peter, Tulin, Alex

Journal:

Leukemia and Lymphoma

Year:

2018

Language:

english

File:

PDF, 808 KB

english, 2018

17

Signal Transducer and Activator of Transcription (STAT)5 Activation by BCR/ABL Is Dependent on Intact Src Homology (SH)3 and SH2 Domains of BCR/ABL and Is Required for Leukemogenesis

Nieborowska-Skorska, M., Wasik, M. A., Slupianek, A., Salomoni, P., Kitamura, T., Calabretta, B., Skorski, T.

Journal:

Journal of Experimental Medicine

Year:

1999

Language:

english

File:

PDF, 247 KB

english, 1999

18

TGFÎ²R-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment

Le, Bac Viet, Podszywalow-Bartnicka, Paulina, Maifrede, Silvia, Sullivan-Reed, Katherine, Nieborowska-Skorska, Margaret, Golovine, Konstantin, Yao, Juo-Chin, Nejati, Reza, Cai, Kathy Q., Caruso, Lisa

Journal:

Year:

2020

File:

PDF, 6.67 MB

2020

19

A preliminary study of apoptosis induction in glioma cells via alteration of the Bax/Bcl-2-p53 axis by transformed and non-transformed root extracts ofLeonurus sibiricusL.

Sitarek, Przemysław, Skała, Ewa, Toma, Monika, Wielanek, Marzena, Szemraj, Janusz, Nieborowska-Skorska, Malgorzata, Kolasa, Maciej, Skorski, Tomasz, Wysokińska, Halina, Śliwiński, Tomasz

Journal:

Year:

2016

Language:

english

File:

PDF, 1.44 MB

english, 2016

20

Antisense oligodeoxynucleotide combination therapy of primary chronic myelogenous leukemia blast crisis in SCID mice

Skorski, T, Nieborowska-Skorska, M, Wlodarski, P, Zon, G, Iozzo, RV, Calabretta, B

Journal:

Year:

1996

File:

PDF, 2.97 MB

1996

21

AKT-induced reactive oxygen species generate imatinib-resistant clones emerging from chronic myeloid leukemia progenitor cells

Nieborowska-Skorska, M, Flis, S, Skorski, T

Journal:

Year:

2014

Language:

english

File:

PDF, 608 KB

english, 2014

22

Suppression of Philadelphia1 leukemia cell growth in mice by BCR-ABL antisense oligodeoxynucleotide.

Skorski, T., Nieborowska-Skorska, M., Nicolaides, N. C., Szczylik, C., Iversen, P., Iozzo, R. V., Zon, G., Calabretta, B.

Journal:

Proceedings of the National Academy of Sciences

Year:

1994

Language:

english

File:

PDF, 1.34 MB

english, 1994

23

MLL-AF9 leukemias are sensitive to PARP1 inhibitors combined with cytotoxic drugs

Maifrede, Silvia, Martinez, Esteban, Nieborowska-Skorska, Margaret, Di Marcantonio, Daniela, Hulse, Michael, Le, Bac Viet, Zhao, Huaqing, Piwocka, Katarzyna, Tempera, Italo, Sykes, Stephen M., Skorski

Journal:

Year:

2017

File:

PDF, 115 KB

2017

24

Tyrosine kinase inhibitor-induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors

Maifrede, Silvia, Nieborowska-Skorska, Margaret, Sullivan, Katherine, Dasgupta, Yashodhara, Podszywalow-Bartnicka, Paulina, Le, Bac Viet, Solecka, Martyna, Lian, Zhaorui, Belyaeva, Elizaveta A, Nerses

Journal:

Year:

2018

Language:

english

File:

PDF, 1.85 MB

english, 2018

25

Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells

Skorski, T, Kanakaraj, P, Nieborowska-Skorska, M, Ratajczak, MZ, Wen, SC, Zon, G, Gewirtz, AM, Perussia, B, Calabretta, B

Journal:

Year:

1995

File:

PDF, 3.15 MB

1995

26

Id1 Transcription Inhibitor-Matrix Metalloproteinase 9 Axis Enhances Invasiveness of the Breakpoint Cluster Region/Abelson Tyrosine Kinase-Transformed Leukemia Cells

Nieborowska-Skorska, M.

Journal:

Cancer Research

Year:

2006

Language:

english

File:

PDF, 597 KB

english, 2006

27

ATR-Chk1 Axis Protects BCR/ABL Leukemia Cells from the Lethal Effect of DNA Double-Strand Breaks

Nieborowska-Skorska, Margaret, Stoklosa, Tomasz, Datta, Mandrita, Czechowska, Agnieszka, Rink, Lori, Slupianek, Artur, Koptyra, Mateusz, Seferynska, Ilona, Krszyna, Konrad, Blasiak, Janusz, Skorski, T

Journal:

Year:

2006

Language:

english

File:

PDF, 646 KB

english, 2006

28

The SH3 Domain Contributes to BCR/ABL-Dependent Leukemogenesis In Vivo: Role in Adhesion, Invasion, and Homing

Skorski, Tomasz, Nieborowska-Skorska, Malgorzata, Wlodarski, Pawel, Wasik, Mariusz, Trotta, Rossana, Kanakaraj, Palanisamy, Salomoni, Paolo, Antonyak, Mark, Martinez, Robert, Majewski, Miroslaw, Wong,

Journal:

Year:

1998

File:

PDF, 482 KB

1998

29

BCR/ABL Inhibits Mismatch Repair to Protect from Apoptosis and Induce Point Mutations

Stoklosa, T., Poplawski, T., Koptyra, M., Nieborowska-Skorska, M., Basak, G., Slupianek, A., Rayevskaya, M., Seferynska, I., Herrera, L., Blasiak, J., Skorski, T.

Journal:

Cancer Research

Year:

2008

Language:

english

File:

PDF, 329 KB

english, 2008

30

Suppression of Philadelphia leukema cell growth in mice by bcr-abl antisense oligodeoxynucleotides

Calabretta, B., Skorski, T., Nieborowska-Skorska, M., Nicolaides, N.C., Szczylik, C., Iversen, P., Zon, G.

Journal:

European Journal of Cancer

Year:

1993

Language:

english

File:

PDF, 148 KB

english, 1993

31

Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells

Bolton-Gillespie, E., Schemionek, M., Klein, H.-U., Flis, S., Hoser, G., Lange, T., Nieborowska-Skorska, M., Maier, J., Kerstiens, L., Koptyra, M., Muller, M. C., Modi, H., Stoklosa, T., Seferynska, I

Journal:

Year:

2013

Language:

english

File:

PDF, 1.12 MB

english, 2013

32

BCR/ABL-mediated leukemogenesis requires the activity of the small GTP-binding protein Rac

Skorski, T., Wlodarski, P., Daheron, L., Salomoni, P., Nieborowska-Skorska, M., Majewski, M., Wasik, M., Calabretta, B.

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 207 KB

english, 1998

33

Progressive changes in the leukemogenic signaling in BCR/ABL-transformed cells

Nieborowska-Skorska, M, Slupianek, A, Skorski, T

Journal:

Year:

2000

Language:

english

File:

PDF, 371 KB

english, 2000

34

BCR/ABL-Mediated Leukemogenesis Requires the Activity of the Small GTP-Binding Protein Rac

Tomasz Skorski, Pawel Wlodarski, Laurence Daheron, Paolo Salomoni, Malgorzata Nieborowska-Skorska, Miroslaw Majewski, Mariusz Wasik and Bruno Calabretta

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 981 KB

english, 1998

35

Inhibition of the mutated c-KIT kinase in AML1-ETOâpositive leukemia cells restores sensitivity to PARP inhibitor

Nieborowska-Skorska, Margaret, Paietta, Elisabeth M., Levine, Ross L., Fernandez, Hugo F., Tallman, Martin S., Litzow, Mark R., Skorski, Tomasz

Journal:

Year:

2019

File:

PDF, 856 KB

2019

36

Suppression of Philadelphia1Leukemia Cell Growth in Mice by BCR-ABL Antisense Oligodeoxynucleotide

Tomasz Skorski, Malgorzata Nieborowska-Skorska, Nicholas C. Nicolaides, Cezary Szczylik, Patrick Iversen, Renato V. Iozzo, Gerald Zon and Bruno Calabretta

Journal:

Proceedings of the National Academy of Sciences

Year:

1994

Language:

english

File:

PDF, 1.16 MB

english, 1994

37

IGH/MYC Translocation Associates with BRCA2 Deficiency and Synthetic Lethality to PARP1 Inhibitors

Maifrede, Silvia, Martin, Kayla, Podszywalow-Bartnicka, Paulina, Sullivan, Katherine, Langer, Samantha K, Nejadi, Reza, Dasgupta, Yashodhara, Hulse, Michael, Gritsyuk, Daniel, Nieborowska-Skorska, Mar

Journal:

Molecular Cancer Research

Year:

2017

File:

PDF, 752 KB

2017

38

Antileukemia Effect of c-myc N3′→ P5′Phosphoramidate Antisense Oligonucleotides in vivo

Tomasz Skorski, Danilo Perrotti, Malgorzata Nieborowska-Skorska, Sergei Gryaznov and Bruno Calabretta

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.71 MB

english, 1997

39

BCR/ABL Regulates Mammalian RecA Homologs, Resulting in Drug Resistance

Artur Slupianek, Christoph Schmutte, Gregory Tombline, Malgorzata Nieborowska-Skorska, Grazyna Hoser, Michal O. Nowicki, Andrew J. Pierce, Richard Fishel, Tomasz Skorski

Journal:

Year:

2001

Language:

english

File:

PDF, 568 KB

english, 2001

40

Blastic Transformation of p53-Deficient Bone Marrow Cells by p210bcr/ablTyrosine Kinase

Tomasz Skorski, Malgorzata Nieborowska-Skorska, Pawel Wlodarski, Danilo Perrotti, Robert Martinez, Mariusz A. Wasik and Bruno Calabretta

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 1.65 MB

english, 1996

41

Treatment of Philadelphia1 Leukemia in Severe Combined Immunodeficient Mice by Combination of Cyclophosphamide and bcr/abl Antisense Oligodeoxynucleotides

Skorski, T., Nieborowska-Skorska, M., Wlodarski, P., Perrotti, D., Majewski, M., Iozzo, R. V., Calabretta, B., Hoser, G., Kawiak, J., Christensen, L.

Journal:

JNCI Journal of the National Cancer Institute

Year:

1997

Language:

english

File:

PDF, 430 KB

english, 1997

42

BCR/ABL Recruits p53 Tumor Suppressor Protein to Induce Drug Resistance

Stoklosa, Tomasz, Slupianek, Artur, Datta, Mandrita, Nieborowska-Skorska, Margaret, Nowicki, Michal O., Koptyra, Mateusz, Skorski, Tomasz

Journal:

Year:

2004

Language:

english

File:

PDF, 936 KB

english, 2004

43

Downregulation of BRCA1 protein in BCR-ABL1 leukemia cells depends on stress-triggered TIAR-mediated suppression of translation

Podszywalow-Bartnicka, Paulina, Wolczyk, Magdalena, Kusio-Kobialka, Monika, Wolanin, Kamila, Skowronek, Krzysztof, Nieborowska-Skorska, Margaret, Dasgupta, Yashodhara, Skorski, Tomasz, Piwocka, Katarz

Journal:

Year:

2014

Language:

english

File:

PDF, 1.38 MB

english, 2014

44

Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells

Sullivan-Reed, Katherine, Bolton-Gillespie, Elisabeth, Dasgupta, Yashodhara, Langer, Samantha, Siciliano, Micheal, Nieborowska-Skorska, Margaret, Hanamshet, Kritika, Belyaeva, Elizaveta A., Bernhardy,

Journal:

Year:

2018

Language:

english

File:

PDF, 2.86 MB

english, 2018

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